The 2nd Notre Dame-Europe Symposium on Nuclear Science and Society (SNSS15) was held at the Notre Dame Rome Center during November 4-6, 2015. Website The first in this series of symposia, organized by the Nuclear Physics Group at the University of Notre Dame, was held at the Notre Dame London Center in October, 2014 (http://isnap.nd.edu/events/NSS2014/). These symposia aim to discuss the current trends in applied nuclear science and it is envisioned that each will highlight selected applications of nuclear science benefitting society in general. The primary focus of the Rome Symposium will be on applications of nuclear science in the areas of art, archaeology, architecture, and environment; at the London symposium, it was medical physics and energy applications. Our endeavor is to bring together practitioners of the techniques of nuclear physics in varied applications for discussions/cross fertilization of ideas.