ISNAP is a University of Notre Dame Research Center focused on fundamental and applied low energy nuclear physics.

ISNAP faculty members perform their research at Notre Dame's Nuclear Science Laboratory (NSL), but are also actively involved in research and development projects at Argonne National Laboratory and at the Facility of Radioactive Ion Beams (FRIB) at Michigan State University. ISNAP operates the NSL, which is a mid-sized accelerator facility dedicated to low energy nuclear physics research. The NSL research activities are supported by the US National Science Foundation. ISNAP is also a founding member of the Joint Institute for Nuclear Astrophysics - Center for the Evolution of the Elements (JINA-CEE). JINA-CEE was an NSF physics frontier center with Michigan State University, University of Notre Dame, Arizona State University, and University of Washington as core institutions.