The Nuclear Science Laboratory (NSL) at the University of Notre Dame (ND) is a mid-sized accelerator laboratory serving the local nuclear physics group and a large growing national and international user community. The research focus of the ND nuclear physics group is on nuclear astrophysics, nuclear structure, and reaction physics. This is complemented by new, frequently interdisciplinary initiatives in the development of accelerator applications and in questions associated with nuclear reactions in plasma environments. The ND faculty continues to be very successful in maintaining a competitive scientific program at the NSL with a number of significant scientific achievements, developments of new instrumentation, and substantial improvements to the laboratory infrastructure. The NSL, its faculty and students serve as a national and international resource in nuclear physics and beyond, providing some unique beams, instrumentation, and student training opportunities.